| 货号 | 1496/50 |
| 别名 | Anthra[1-9-cd]pyrazol-6(2H)-one |
| 供应商 | Tocris |
| 生物活性 | Selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Prevents BMP9-induced osteogenic differentiation of MSCs. Essential component of medium for maintaining stem cells in naive pluripotent state. Available as part of the MAPK Inhibitor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 220.23 |
| 分子式 | C14H8N2O |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO |
| CAS号 | 129-56-6 |
| 参考文献 | Gafniet al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903. Zhaoet al (2013) Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep. 46 422. PMID: 23977991. Wanget al (2007) SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis. Life Sci. 80 2067. PMID: 17459422. Bennettet al (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc.Natl.Acad.Sci.U.S.A. 98 13681. PMID: 11717429. Schnablet al (2001) TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology 34 953. PMID: 11679966. |