| 货号 | 2684/50 |
| 别名 | (4S)-4,11-Diethyl-4,9-dihydroxy-1H- |
| 供应商 | Tocris |
| 生物活性 | Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 392.4 |
| 分子式 | C22H20N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 86639-52-3 |
| 参考文献 | Koizumiet al (2006) Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res. 66 10048. PMID: 17047068. Gaoet al (2005) Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 15 3233. PMID: 15913996. Kawatoet al (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 51 4187. PMID: 1651156. |