| 货号 | 4231/50 |
| 别名 | N-[[4-(1-Methylethyl)cyclohexyl]car |
| 供应商 | Tocris |
| 生物活性 | Kir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+concentration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 317.42 |
| 分子式 | C19H27NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Chachinet al (2003) Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels. J.Pharmacol.Exp.Ther. 304 1025. PMID: 12604678. Huet al (1999) Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell KATP channels. J.Pharmacol.Exp.Ther. 291 1372. PMID: 10565863. Fujitaniet al (1997) The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 120 1191. PMID: 9105692. Shinkaiet al (1989) N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 32 1436. PMID: 2738878. |