| 货号 | 2146/50 |
| 别名 | N,N''-1,4-Butanediylbis[N'-(3-isothioc |
| 供应商 | Tocris |
| 生物活性 | Selective antagonist of P2Y6 nucleotide receptors; IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4 and P2Y11 receptors (IC50 > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 472.66 |
| 分子式 | C20H20N6S4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 711019-86-2 |
| 参考文献 | Koizumiet al (2007) UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446 1091. PMID: 17410128. Kukulskiet al (2007) Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J.Leukoc.Biol. 81 1269. PMID: 17322022. Mamedovaet al (2004) Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem.Pharmacol. 67 1763. PMID: 15081875. |