| 货号 | 3622/50 |
| 别名 | 1,1'-Dithiodi-2-naphthtol |
| 供应商 | Tocris |
| 生物活性 | Group I p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo; potential anti-tumor agent. Negative control PIR 3.5 (Cat. No. 4212) available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >96 % |
| 计算分子量 | 350.45 |
| 分子式 | C20H14O2S2 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 10 mM in ethanol with gentle warming |
| CAS号 | 42521-82-4 |
| 参考文献 | Wanget al (2016) P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate. PLoS One 11 e0153312. PMID: 27071060. Takahashi and Suzuki (2009) Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/op18 to Pak1-WAVE2-kinesin complex. Cell.Signal. 21 695. PMID: 19162178. Viaud and Peterson (2009) An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently. Mol.Cancer Ther. 8 2559. PMID: 19723886. Deaconet al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322. PMID: 18420139. Kumaret al (2006) p21-activated kinases in cancer. Nat.Rev.Cancer 6 459. PMID: 16723992. |