| 货号 | 3270/50 |
| 别名 | 4,5-Dihydro-3-phenyl-5-isoxazoleace |
| 供应商 | Tocris |
| 生物活性 | Orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic; prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 205.21 |
| 分子式 | C11H11NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 6501-72-0 |
| 参考文献 | Manganoet al(2008)In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur.J.Pharmacol. 586 313. PMID: 18374912. Stojanovicet al(2007)In vitro,ex vivoandin vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin.Immunol. 123 311. PMID: 17449326. Stosic-Grujicicet al (2007) A potent immunomodulatory compound (S,R)-3-phenyl-4,5-dihydro-5-isoxasoleacetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J.Pharmacol.Exp.Ther. 320 1038. PMID: 17148780. |