| 货号 | 3414/50 |
| 别名 | 1,2,4,5-Benzenetetramine tetrahydrochloride |
| 供应商 | Tocris |
| 生物活性 | Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 284.01 |
| 分子式 | C6H10N4.4HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 75 mM in DMSO |
| CAS号 | 4506-66-5 |
| 参考文献 | Hochwaldet al (2009) A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 8 2435. PMID: 19571674. Golubovskayaet al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth. J.Med.Chem. 51 7405. PMID: 18989950. |