| 货号 | 2709/50 |
| 别名 | (2Z)-7-[[(2R)-2-Amino-2-carboxyethy |
| 供应商 | Tocris |
| 生物活性 | Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 380.43 |
| 分子式 | C16H25N2NaO5S |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 10 mM in DMSO |
| CAS号 | 81129-83-1 |
| 参考文献 | Perezet al (2004) Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrol.Dial.Transplant. 19 2445. PMID: 15252165. Whiteet al (1999) A continuous fluorometric assay for leukotriene D4 hydrolase. Anal.Biochem. 268 245. PMID: 10075814. Grahamet al (1987) Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J.Med.Chem. 30 1074. PMID: 3495664. |