LY2784544
货号：
16705-25mg 基本售价：
6762.0 元 规格：
25 mg
产品信息
概述| 货号 | 16705-25mg |
| 描述 | LY2784544 is a potent, ATP-competitive inhibitor of janus kinase 2 (JAK2) that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively).1 It also inhibits JAK2 containing the V617F mutation (IC50 = 20 nM), blocking STAT5 phosphorylation and proliferation of Ba/F3 pro-B-cells expressing this constitutively active JAK2 mutant form.1 When given by oral gavage, LY2784544 significantly reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets.1 JAK inhibitors, including LY2784544, may be useful in hematological malignancies.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ma, L.,Clayton, J.R.,Walgren, R.A., et al. Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer J. 3, 1-11 (2013).
2.Furqan, M.,Mukhi, N.,Lee, B., et al. Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application. Biomark.Res. 1(1), 1-10 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470 |
| 分子式 | C23H25ClFN7O |
| CAS号 | 1229236-86-5 |
| 稳定性 | ≥ 2 years |
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