| 货号 | 20230-100ug |
| 描述 | 11-trans Leukotriene C4(11-transLTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-transLTC4 during storage. 11-transLTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils1, but not in human neutrophils or RBL-1 cells.2 It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.3,4 In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-transLTC4 were determined to be 6.42 and 6.58, respectively.4 |
| 别名 | 11-transLTC4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jörg, A.,Henderson, W.R.,Murphy, R.C., et al. Leukotriene generation by eosinophils. Journal of Experimental Medicine 155, 390-402 (1982). 2.Macchia, L.,Hamberg, M.,Kumlin, M., et al. Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane. Biochimica et Biophysica Acta 1257, 58-74 (1995). 3.Dahlén, S.E.,Hedqvist, P., and Hammarström, S. Contractile activities of several cysteine-containing leukotrienes in the guinea-pig lung strip. European Journal of Pharmacology 86, 207-215 (1983). 4.Sala, A.,Civelli, M.,Oliva, D., et al. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum. Eicosanoids 3, 105-110 (1990). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 625.8 |
| 分子式 | C30H47N3O9S |
| CAS号 | 74841-69-3 |
| 稳定性 | ≥ 1 year |
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