| 货号 | 20190-100ug |
| 描述 | 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL,1 but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM).2 However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung.3 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2receptor,4,5 but does not appear to function as an agonist.6 |
| 别名 | 20-hydroxy LTB4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Feinmark, S.J.,Lindgren, J.Å.,Claesson, H.E., et al. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites. FEBS Letters 136, 141-144 (1981). 2.Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. Journal of Pharmacology and Experimental Therapeutics 255, 565-571 (1990). 3.Hansson, G.,Lindgren, J.Å.,Dahlén, S.E., et al. Identification and biological activity of novel w -oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Letters 130, 107-112 (1981). 4.Wang, S.,Gustafson, E.,Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275, 40686-40694 (2000). 5.Yokomizo, T.,Kato, K.,Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001). 6.Kamohara, M.,Takasaki, J.,Matsumoto, M., et al. Molecular cloning and characterization of another leukotriene B4 receptor. The Journal of Biological Chemisty 275, 27000-27004 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 79516-82-8 |
| 稳定性 | ≥ 1 year |
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