| 货号 | 20140-100ug |
| 描述 | Leukotriene B4(LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4formedvia the LTB4 12-hydroxydehydrogenase pathway.1,2,3 It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4.212-oxo-LTB4(EC50 = 33 nM) is about 70-fold less potent than LTB4(EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils.4 It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.4 |
| 别名 | 12-keto LTB4;12-oxo LTB4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yokomizo, T.,Izumi, T.,Takahashi, T., et al. Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. The Journal of Biological Chemisty 268, 18128-18135 (1993). 2.Wainwright, S.L., and Powell, W.S. Mechanism for the formation of dihydro metabolites of 12-hydroxyeicosanoids conversion of leukotriene B4 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid to 12-oxo intermediates. The Journal of Biological Chemisty 266(31), 20899-20906 (1991). 3.Wheelan, P.,Zirrolli, J.A.,Morelli, J.G., et al. Metabolism of leukotriene B4 by cultural human keratinocytes. Formation of glutathione conjugates and dihydro metabolites. The Journal of Biological Chemisty 268, 25439-25448 (1993). 4.Powell, W.S.,Rokach, J.,Khanapure, S.P., et al. Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. Journal of Pharmacology and Experimental Therapeutics 276(2), 728-736 (1996). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 计算分子量 | 334.4 |
| 分子式 | C20H30O4 |
| CAS号 | 136696-10-1 |
| 稳定性 | ≥ 1 year |
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