| 货号 | 20135-100ug |
| 描述 | Leukotriene B4(LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4(LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epiLTB4. 12-epiLTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4hydrolase.1 Compared to LTB4, 12-epiLTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM),2 and on guinea pig lung membranes with a (Ki of 4.7 mM).312-epiLTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.4 |
| 别名 | 12-epiLTB4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sala, A.,Bolla, M.,Zarini, S., et al. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. The Journal of Biological Chemisty 271, 17944-17948 (1996). 2.Jackson, R.H.,Morrissey, M.M.,Sills, M.A., et al. Comparison of antagonist and agonist binding to the leukotriene B4 receptor on intact human polymorphonuclear neutrophils (PMN). Journal of Pharmacology and Experimental Therapeutics 262(1), 80-89 (1992). 3.Cristol, J.P.,Provençal, B.,Borgeat, P., et al. Characterization of leukotriene B4 binding sites on guinea pig lung macrophages. Journal of Pharmacology and Experimental Therapeutics 247(3), 1199-1203 (1988). 4.Yokomizo, T.,Kato, K.,Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 336.5 |
| 分子式 | C20H32O4 |
| CAS号 | 83709-73-3 |
| 稳定性 | ≥ 1 year |
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