12-epi Leukotriene B3
货号：
20134-100ug 基本售价：
6748.0 元 规格：
100 ug
产品信息
概述| 货号 | 20134-100ug |
| 描述 | 12-epiLTB3 is an LTB isomer that would not be formed either by known enzymatic or non-enzymatic processes. The conversion of LTA into different isomers of LTB is complex, and has generated confusion in the past. The enzymatic hydrolysis of LTA leads to LTB, which is the corresponding 5(S),12(R)-dihydroxy acid containing a 6(Z),8(E),10(E) conjugated triene. Non-enzymatic hydrolysis of LTA produces none of this material, but instead produces both the 12(S) and the 12(R) isomers of LTB in which the triene component now contains a 6-trans double bond.112-epi (or 12(S)) LTB isomers which contain the natural 6-cis olefin are not produced either by enzymatic or by non-enzymatic processes. Further, 3-series LTs (derived from Mead acid) are only seen in essential fatty acid deficiency. Mead acid is a good substrate for 5-lipoxygenase, leading to LTA3. Enzymatic conversion of LTA3 to LTB3 is very low because LTA3 is actually an inhibitor of LTA hydrolase.2 Non-enzymatic hydrolysis of LTA3 leads to 6-trans-12-epiLTB3, and to 6-trans LTB3. The biological activity of 12-epiLTB3 has not been explored. |
| 别名 | 12-epiLTB3; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sala, A.,Bolla, M.,Zarini, S., et al. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. The Journal of Biological Chemisty 271, 17944-17948 (1996).
2.Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 20, 224-231 (1990).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 338.5 |
| 分子式 | C20H34O4 |
| 稳定性 | ≥ 1 year |
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