CPI-455
货号：
22127-25mg 基本售价：
6734.0 元 规格：
25 mg
产品信息
概述| 货号 | 22127-25mg |
| 描述 | CPI-455 is an inhibitor of the lysine demethylase 5 family (KDM5A-D).1 CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D(IC50s = 2-10 nM) over KDM2-5, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations. CPI-455 also reduces growth of glioblastoma cells resistant to temozolomide (TMZ; Item No. 14163) in a dose-dependent manner.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vinogradova, M.,Gehling, V.S.,Gustafson, A., et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat. Chem. Biol. 12(7), 531-538 (2016).
2.Banelli, B.,Daga, A.,Forlani, A., et al. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget 8(21), 34896-34910 (2017).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 278.3 |
| 分子式 | C16H14N4O |
| CAS号 | 1628208-23-0 |
| 稳定性 | ≥ 2 years |
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