| 货号 | 18465-10mg |
| 描述 | Atorvastatin (Item No. 10493) is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective against hypercholesterolemia and certain dyslipidemias.1,2,3 Atorvastatin can exist in four optical forms, with the 3R,5R enantiomer displaying the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.4 It also differs from other atorvastatin enantiomers in cytotoxicity, activation of the pregnane X receptor, and induction of cytochrome P450 isoforms.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dart, A.,Jerums, G.,Nicholson, G., et al. A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia. American Journal of Cardiology 80, 39-44 (1997). 2.The Diabetes Atorvastatin Lipid Intervention Study, G. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia. The DALI study: A double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia. Diabetes Care 24(8), 1335-1341 (2001). 3.van Dam, M.,Zwart, M.,de Beer, F., et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia. Heart 88, 234-238 (2002). 4.Kocarek, T.A.,Dahn, M.S.,Cai, H., et al. Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metabolism and Disposition 30(12), 1400-1405 (2002). 5.Korhonova, M.,Doricakova, A., and Dvorak, Z. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. PLoS One 10(9), (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 580.6 |
| 分子式 | C33H34FN2O5 • Na |
| CAS号 | 1428118-38-0 |
| 稳定性 | ≥ 2 years |
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