| 货号 | 11899-2.5mg |
| 描述 | Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.1,2 At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.1 Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.3 As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.4 |
| 别名 | Antibiotic 1233A;Antibiotic F 244;L 659699; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Greenspan, M.D.,Yudkovitz, J.B.,Lo, C.Y.L., et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proceedings of the National Academy of Sciences of the United States of America 84, 7488-7492 (1987). 2.Tomoda, H.,Ohbayashi, N.,Morikawa, Y., et al. Binding site for fungal β-lactone hymeglusin on cytosolic 3- hydroxy-3-methylglutaryl coenzyme A synthase. Biochimica et Biophysica Acta 1636, 22-28 (2004). 3.Tomoda, H.,Ohbayashi, N.,Kumagai, H., et al. Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of β-lactone DU-6622. Biochemical and Biophysical Research Communications 265(2), 536-540 (1999). 4.Balibar, C.J.,Shen, X.,McGuire, D., et al. cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology 156, 1372-1383 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 324.4 |
| 分子式 | C18H28O5 |
| CAS号 | 29066-42-0 |
| 稳定性 | ≥ 3 years |
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