SB-525334
货号：
2880-25 基本售价：
6673.5 元 规格：
25mg
产品信息
概述| 货号 | 2880-25 |
| 描述 | SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC₅₀ > 10,000 nM). In cell-based assays, SB-525334 (1 µM) blocks TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen α1(I) mRNA expression in A498 renal epithelial carcinoma cells. |
性能| 供应商 | Biovision |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 外观 | Orange solid |
