23-cGAMP
货号：
19887-1mg 基本售价：
6650.0 元 规格：
1 mg
产品信息
概述| 货号 | 19887-1mg |
| 描述 | 2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.1,2,3 It binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), cyclic di-GMP (Item No. 17144), and 3’2’-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively).3 It is a potent inducer of IFN-β production with an EC50 value of 19.4 nM in L929 cells.3 |
| 别名 | Guanosine-Adenosine 2,3-cyclic monophosphate;2-3-Cyclic GMP-AMP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wu, J.,Sun, L.,Chen, X., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121), 826-830 (2013).
2.Sun, L.,Wu, J.,Du, F., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121), 786-791 (2013).
3.Zhang, X.,Shi, H.,Wu, J., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51(2), 226-235 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 674.4 |
| 分子式 | C20H24N10O13P2 |
| CAS号 | 1441190-66-4 |
| 稳定性 | ≥ 2 years |
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