Z-VRPR-FMK (trifluoroacetate salt)
货号：
19617-1mg 基本售价：
6650.0 元 规格：
1 mg
产品信息
概述| 货号 | 19617-1mg |
| 描述 | Z-VRPR-FMK is a selective, irreversible inhibitor of the paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an endopeptidase that targets BCL10 and reduces NF-κB activation in lymphocytes at 12.5 to 75 µM.1,2,3 Other MALT1 substrates that may be affected by Z-VRPR-FMK are TNFAIP3 and CYLD.3 |
| 别名 | Z-Val-Arg-Pro-DL-Arg-FMK; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rebeaud, F.,Hailfinger, S.,Posevitz-Fejfar, A., et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nature Immunology 9(3), 272-281 (2008).
2.Hachmann, J.,Snipas, S.J.,van Raam, B.J., et al. Mechanism and specificity of the human paracaspase MALT1. Biochemistry Journal 443(1), 287-295 (2012).
3.Fernandez-Jimenez, N.,Castellanos-Rubio, A.,Plaza-Izurieta, L., et al. Coregulation and modulation of NF.kapa.B-related genes in celiac disease: Uncovered aspects of gut mucosal inflammation. Human Molecular Genetics 23(5), 1298-1310 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 790.8 |
| 分子式 | C31H49FN10O6 • CF3COOH |
| 稳定性 | ≥ 3 years |
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