Cdk1/2 Inhibitor III
货号：
18859-10mg 基本售价：
6650.0 元 规格：
10 mg
产品信息
概述| 货号 | 18859-10mg |
| 描述 | Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.1 Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively).2 It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases.2,3 Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bettayeb, K.,Baunbaek, D.,Delehouze, C., et al. CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cells. Genes Cancer 1(4), 369-380 (2010).
2.Lin, R.,Connolly, P.J.,Huang, S., et al. 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: Synthesis and evaluation of biological activities. Journal of Medicinal Chemistry 48(13), 4208-4211 (2005).
3.Fedorov, O.,Huber, K.,Eisenreich, A., et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chemistry & Biology 18(1), 67-76 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 425.4 |
| 分子式 | C15H13F2N7O2S2 |
| CAS号 | 443798-47-8 |
| 稳定性 | ≥ 2 years |
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