Balicatib
货号：
17995-50mg 基本售价：
6650.0 元 规格：
50 mg
产品信息
概述| 货号 | 17995-50mg |
| 描述 | Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively).1,2 it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S.2 Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.1,2 |
| 别名 | AAE581; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Desmarais, S.,Black, W.C.,Oballa, R., et al. Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol. Pharmacol. 73(1), 147-156 (2008).
2.Falgueyret, J.-P.,Desmarais, S.,Oballa, R., et al. Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J. Med. Chem. 48(24), 7535-7543 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 411.5 |
| 分子式 | C23H33N5O2 |
| CAS号 | 354813-19-7 |
| 稳定性 | ≥ 2 years |
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