I-BET726
货号：
16872-25mg 基本售价：
6650.0 元 规格：
25 mg
产品信息
概述| 货号 | 16872-25mg |
| 描述 | I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins.1,2 It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs.2 I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling.2 I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.2 |
| 别名 | GSK1324726A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gosmini, R.,Nguyen, V.L.,Toum, J., et al. The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline apoA1 up-regulator and selective BET bromodomain inhibitor. Journal of Medicinal Chemistry 57, 8111-8131 (2014).
2.Wyce, A.,Ganji, G.,Smitheman, K.N., et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One 8(8), e72967 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 435 |
| 分子式 | C26H23ClN2O3 |
| CAS号 | 1300031-52-0 |
| 稳定性 | ≥ 2 years |
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