| 货号 | 16021-1g |
| 描述 | Ciclopirox is an antifungal and cell-permeable iron-chelating agent.1,2 It inhibits iron-dependent enzymes, including prolyl hydroxylase 2 (PHD2; pIC50 = 5.8) and deoxyhypusine hydroxylase.3,4 Through its effect on PHDs, ciclopirox increases the activity of hypoxia-inducible factors HIF-1α and HIF-1β.3,5 |
| 别名 | HOE 296b; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lai, Y.-W.,Campbell, L.T.,Wilkins, M.R., et al. Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus. Int. J. Antimicrob. Agents 48(4), 388-394 (2016). 2.Shen, T. and Huang, S. Repositioning the old fungicide ciclopirox for new medical uses. Curr. Pharm. Des. 22(28), 4443-4450 (2016). 3.Clement, P.M.,Hanauske-Abel, H.M.,Wolff, E.C., et al. The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro. Int. J. Cancer 100(4), 491-498 (2002). 4.Barrett, T.D.,Palomino, H.L.,Brondstetter, T.I., et al. Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor. Molecular Pharmacology 79(6), 910-920 (2011). 5.Li, X.,Guo, Q.,Gao, J., et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K+ channels in pancreatic beta cells. PLoS One 8(10), e77934 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 207.3 |
| 分子式 | C12H17NO2 |
| CAS号 | 29342-05-0 |
| 稳定性 | ≥ 2 years |
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