| 货号 | 14190-1mg |
| 描述 | Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was orignally isolated from the culture broth of S. gilvotanareus.1,2 It is strongly active against Gram-positive bacteria such as S. aureusandB. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.3 Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.4 |
| 别名 | Anandimycin A;Antibiotic 1072B;DC-38-V;NSC 338943;NSC 348115;Toromycin A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wei, T.T.,Byrne, K.M.,Warnick-Pickle, D., et al. Studies on the mechanism of action of gilvocarcin V and chrysomycin A. Journal of Antibiotics 35(4), 545-548 (1982). 2.Nakano, H.,Matsuda, Y.,Ito, K., et al. Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics 34(3), 266-270 (1981). 3.Morimoto, M.,Okubo, S.,Tomita, F., et al. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity. Journal of Antibiotics 34(6), 701-707 (1981). 4.Matsumoto, A. and Hanawalt, P.C. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Cancer Research 60(14), 3921-3926 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 494.5 |
| 分子式 | C27H26O9 |
| CAS号 | 77879-90-4 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |