| 货号 | 5962/50 |
| 别名 | 2-[(3-Amino-2-pyridinyl)methylene]h |
| 供应商 | Tocris |
| 生物活性 | Ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 195.24 |
| 分子式 | C7H9N5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Aridet al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204. PMID: 24486217. Finchet al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3. PMID: 10470363. Liuet al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672. PMID: 1433178. |