PBIT ( )
货号：
5930/50 基本售价：
6622.9 元 规格：
50 mg
产品信息
概述| 货号 | 5930/50 |
| 别名 | 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one |
性能| 供应商 | Tocris |
| 生物活性 | JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50 values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 241.31 |
| 分子式 | C14H11NOS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Sayeghet al (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J.Biol.Chem. 288 9408. PMID: 23408432. |
