| 货号 | 4746/50 |
| 别名 | 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1 |
| 供应商 | Tocris |
| 生物活性 | Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 362.42 |
| 分子式 | C22H22N2O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Shenet al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731. PMID: 22415822. Weisset al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111. PMID: 22808310. |