| 货号 | 4060/50 |
| 别名 | 2,3-Dichloro-α-methylbenzylamine hydrochloride |
| 供应商 | Tocris |
| 生物活性 | High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μMin vitro). Suppresses the release of growth hormone in an in vivo rat model. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 226.53 |
| 分子式 | C8H9Cl2N.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO with gentle warming |
| 参考文献 | Grunewaldet al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824. PMID: 3351861. Terryet al (1982) Regulation of episodic growth hormone secretion by the central epinephrine system. J.Clin.Invest. 69 104. PMID: 7054231. Fulleret al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106. PMID: 4683104. |