| 货号 | 0438/50 |
| 别名 | 1-Ethyl-4-[(1-methylethylidene)hydr |
| 供应商 | Tocris |
| 生物活性 | Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 325.8 |
| 分子式 | C14H19N5O2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 51022-77-6 |
| 参考文献 | Ahluwalia and Nicholsonet al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19. PMID: 1848733. Rhoads (1982) Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 31 665. PMID: 6177320. Chesinet al (1972) 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 21 2443. PMID: 4345859. |