10(R)-PAHSA
货号：
21362-1mg 基本售价：
6622.0 元 规格：
1 mg
产品信息
概述| 货号 | 21362-1mg |
| 描述 | 10(R)-PAHSA is a stereoisomer of 10-PAHSA (Item No. 19973), an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is an FAHFA in which palmitic acid (Item No. 10006627) is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.1,2 A study using synthesized (R)- and (S)- stereoisomers of 9-PAHSA (Item No. 17037) reported that the 9(R)-PAHSA (Item No. 18022) is the predominant form that accumulates in adipose tissues in vivo.3 Also, cell lines favor the production of 9(R)-PAHSA and carboxyl ester lipase selectively hydrolyzes 9(S)-PAHSA (Item No. 18023).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yore, M.M.,Syed, I.,Moraes-Vieira, P.M., et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 159(2), 318-332 (2014).
2.Moraes-Vieira, P.M.,Saghatelian, A. and Kahn, B.B. GLUT4 Expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-inflammatory effects. Diabetes 65(7), 1808-1815 (2016).
3.Nelson, A.T.,Kolar, M.J.,Chu, Q., et al. Stereochemistry of endogenous palmitic acid ester of 9-hydroxystearic acid and relevance of absolute configuration to regulation. J. Am. Chem. Soc. 139(13), 4943-4947 (2017).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 538.9 |
| 分子式 | C34H66O4 |
| 稳定性 | ≥ 2 years |
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