C-7280948
货号：
21601-1g 基本售价：
6608.0 元 规格：
1 g
产品信息
概述| 货号 | 21601-1g |
| 描述 | C-7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 12.8 µM, in vitro).1,2 PRMT1 enzymes transfer a methyl group from S-adenosylmethionine to arginine residues on histones, which leads to transcription.2 PRMT1 is essential for mixed lineage leukemia oncogenic transformation and thus its inhibition is a potential treatment for these aggressive leukemias.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Luo, M. Current chemical biology approaches to interrogate protein methyltransferases. ACS Chem Biol. 7(3), 443-463 (2012).
2.Heinke, R.,Spannhoff, A.,Meier, R., et al. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. Chem. Med. Chem. 4(1), 69-77 (2009).
3.Muntean, A.G., and Hess, J.L. The pathogenesis of mixed-lineage leukemia. Annu. Rev. Pathol. 7, 283-301 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 276.4 |
| 分子式 | C14H16N2O2S |
| CAS号 | 587850-67-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
