Apoptozole
货号：
17675-50mg 基本售价：
6608.0 元 规格：
50 mg
产品信息
概述| 货号 | 17675-50mg |
| 描述 | Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.1 It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).1 It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.1 Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.2 |
| 别名 | Apoptosis Activator VII; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ko, S.K.,Kim, J.,Na, D.C., et al. A small molecule inhibitor of ATPase activity of HSP70 iduces apoptosis and has antitumor activities. Chemistry & Biology 22(3), 391-403 (2015).
2.Ljung, B. Vascular selectivity of felodipine: Experimental pharmacology. Journal of Cardiovascular Pharmacology 15(Suppl 4), S11-S16 (1990).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 625.6 |
| 分子式 | C33H25F6N3O3 |
| CAS号 | 1054543-47-3 |
| 稳定性 | ≥ 2 years |
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