| 货号 | 17596-10g |
| 描述 | N,N’-Diacetyl-L-cystine (DiNAC) is a disulfide dimer of N-acetylcysteine with immunomodulatory properties. Its intact disulfide bridge has been shown to be important for its ability to modify contact sensitivity/delayed hypersensitivity reactions in mice.1,2 At 3 µM/kg/day, DiNAC also demonstrates anti-atherosclerotic effects, improving endothelial function in Watanabe heritable hyperlipidemic rabbits.2,3,4 |
| 别名 | N,N’-Diacetylcystine;DiNAC;NSC 203780; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Särnstrand, B.,Jansson, A.H.,Matuseviciene, G., et al. N,N-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. Journal of Pharmacology and Experimental Therapeutics 288(3), 1174-1184 (1999). 2.Pettersson, K., and Bergstrand, H. The antiatherogenic effect of DiNAC: Experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases. Cardiovascular Drug Reviews 21(2), 119-132 (2003). 3.Wågberg, M.,Jansson, A.H.,Westerlund, C., et al. N,N-Diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: Evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. Journal of Pharmacology and Experimental Therapeutics 299(1), 76-82 (2001). 4.Pettersson, K.S.,Eliasson, U.B.,Abrahamsson, T., et al. N,N-Diacetyl-L-cystine improves endothelial function in atherosclerotic watanabe heritable hyperlipidaemic rabbits. Basic & Clinical Pharmacology & Toxicology 100, 36-42 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 324.4 |
| 分子式 | C10H16N2O6S2 |
| CAS号 | 5545-17-5 |
| 稳定性 | ≥ 2 years |
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