| 货号 | 16981-50mg |
| 描述 | Lipoic acid (Item No. 10005728) is a natural organosulfur compound that serves as a cofactor in various complexes, including the α-ketoglutarate dehydrogenase complex, which is involved in the citric acid cycle as well as other pathways. CPI-613 is a lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells.1 At 60-240 µM, CPI-613 induces a strong mitochondrial burst of reactive oxygen species, resulting in cell death.1 By disrupting mitochondrial metabolism, CPI-613 demonstrates both in vitroandin vivo anti-tumor activity through both apoptotic and non-apoptotic pathways.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Stuart, S.D.,Schauble, A.,Gupta, S., et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2(1), 1-15 (2014). 2.Lee, K.C.,Shorr, R.,Rodriguez, R., et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab.Lett. 5, 163-182 (2011). 3.Zachar, Z.,Marecek, J.,Maturo, C., et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J.Mol.Med.(Berl.) 89, 1137-1148 (2011). 4.Lee, K.C.,Maturo, C.,Perera, C.N., et al. Translational assessment of mitochondrial dysfunction of pancreatic cancer from in vitro gene microarray and animal efficacy studies, to early clinical studies, via the novel tumor-specific anti-mitochondrial agent, CPI-613. Ann.Transl.Med. 2(9), 1-10 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.6 |
| 分子式 | C22H28O2S2 |
| CAS号 | 95809-78-2 |
| 稳定性 | ≥ 2 years |
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