| 货号 | 14725-10mg |
| 描述 | 15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 (Item No. 14010) analog 15(S)-15-methyl PGE2 (Item No. 14730).1 Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active.2 Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 µg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.3,4 |
| 别名 | Arbaprostil;15(R)-15-methyl PGE2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yankee, E.W.,Axen, U. and Bundy, G.L. Total synthesis of 15-methylprostaglandins. Journal of the American Chemical Society 96, 5865-5876 (1974). 2.Takanashi, H.,Kawabe, Y. and Akima, M. Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats. Japanese Journal of Pharmacology 57, 559-564 (1991). 3.Takanashi, H. and Itoh, Z. Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs. Japanese Journal of Pharmacology 57, 447-451 (1991). 4.Li, J.,Nagata, T.,Yoshida, M., et al. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterology Japan 24, 8-11 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.5 |
| 分子式 | C21H34O5 |
| CAS号 | 55028-70-1 |
| 稳定性 | ≥ 1 year |
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