| 货号 | 14650-10mg |
| 描述 | 13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is the primary metabolite of PGE2 (Item No. 14010) in plasma.1 Endogenous or infused PGE2 is rapidly metabolized by the enzymes 15-hydroxy PGDH and 15-oxo-PG Δ13-reductase to form 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 accumulates to detectable levels; plasma levels in humans are between 10-100 pg/ml.2,3 It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dihydro-15-keto PGE2 is about 9 minutes.3 In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2biosynthesis.4,5 |
| 别名 | 13,14-dihydro-15-keto PGE2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamberg, M. and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971). 2.Fitzpatrick, F.A.,Aguirre, R.,Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE2. Prostaglandins 19, 917-931 (1980). 3.Bothwell, W.,Verburg, M.,Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: An indirect index of their in vivo disposition and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 220, 229-235 (1982). 4.Leonhardt, A.,Krauss, M.,Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. British Journal of Dermatology 136, 337-340 (1997). 5.Granström, E.,Hamberg, M.,Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19, 933-945 (1980). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 363-23-5 |
| 稳定性 | ≥ 2 years |
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