CHS-828
货号：
11021-50mg 基本售价：
6608.0 元 规格：
50 mg
产品信息
概述| 货号 | 11021-50mg |
| 描述 | CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.1,2 CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitroandin vivo.3 In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.3 |
| 别名 | GMX 1778; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hassan, S.B.,Lövborg, H.,Lindhagen, E., et al. CHS 828 kill tumour cells by inhibiting the nuclear factor-κB translocation but unlikely through down-regulation of proteasome. Anticancer Research 26, 4431-4436 (2006).
2.Olesen, U.H.,Petersen, J.G.,Garten, A., et al. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer 10(677), 1-13 (2010).
3.Hjarnaa, P.J.V.,Jonsson, E.,Latini, S., et al. CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Research 59, 5751-5757 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.9 |
| 分子式 | C19H22ClN5O |
| CAS号 | 200484-11-3 |
| 稳定性 | ≥ 2 years |
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