| 货号 | 10011619-1g |
| 描述 | Terbinafine is an antifungal compound that is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast.1 It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans).2 At 90-120 µM, terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Petranyi, G.,Meingassner, J.G. and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob. Agents Chemother. 31(9), 1365-1368 (1987). 2.Ryder, N.S. and Dupont, M.C. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochemistry Journal 230, 765-770 (1985). 3.Lee, W.S.,Chen, R.J.,Wang, Y.J., et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. International Journal of Cancer 106, 125-137 (2003). 4.Ho, P.Y.,Liang, Y.C.,Ho, Y.S., et al. Inhibition of human vascular endothelial cells proliferation by terbinafine. International Journal of Cancer 111, 51-59 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.9 |
| 分子式 | C21H25N • HCl |
| CAS号 | 78628-80-5 |
| 稳定性 | ≥ 2 years |
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