17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
货号：
10010810-10mg 基本售价：
6608.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010810-10mg |
| 描述 | Prostaglandin F2α(PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide.2 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma.3 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid. |
| 别名 | 17-phenyl trinor PGF2α cyclopropyl methyl amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balapure, A.K.,Rexroad, C.E., Jr.,Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochemical Pharmacology 38, 2375-2381 (1989).
2.Camras, C.B.,Toris, C.B.,Sjoquist, B., et al. Detection of the free acid of bimatoprost in aqueous humor samples from human eyes treated with bimatoprost before cataract surgery. Ophthalmology 111(12), 2193-2198 (2004).
3.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. Pharmacological characterization of a novel antiglaucoma agent, bimatoprost (AGN 192024). Journal of Pharmacology and Experimental Therapeutics 305(2), 772-785 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.6 |
| 分子式 | C27H39NO4 |
| CAS号 | 1138395-10-4 |
| 稳定性 | ≥ 2 years |
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