Meleagrin
货号：
17850-5mg 基本售价：
6566.0 元 规格：
5 mg
产品信息
概述| 货号 | 17850-5mg |
| 描述 | Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.1 It is produced as an end product in the roquefortine branched biosynthetic pathway.2,3 Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureusandE. coli FabI, respectively.1 It inhibits the growth of S. aureus,E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.1 |
| 别名 | 6-O-Methyloxaline; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zheng, C.J.,Sohn, M.J.,Lee, S., et al. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action. PLoS One 8(11), (2013).
2.Ali, H.,Ries, M.I.,Nijland, J.G., et al. A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum. PLoS One 8(6), (2013).
3.Ries, M.I.,Ali, H.,Lankhorst, P.P., et al. Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway. The Journal of Biological Chemisty 288(52), 37289-37295 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.5 |
| 分子式 | C23H23N5O4 |
| CAS号 | 71751-77-4 |
| 稳定性 | ≥ 2 years |
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