Foretinib
货号：
16249-25mg 基本售价：
6566.0 元 规格：
25 mg
产品信息
概述| 货号 | 16249-25mg |
| 描述 | Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRβ, and Tie-2, at nanomolar concentrations.1,2 It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in tumor cells and HGV/VEGF-induced responses in endothelial cells.1,3 Foretinib is functional in vivo, reducing tumor burden in an experimental model of lung metastasis.1 |
| 别名 | GSK1363089;XL880; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Qian, F.,Engst, S.,Yamaguchi, K., et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69(20), 8009-8016 (2009).
2.Davis, M.I.,Hunt, J.P.,Herrgard, S., et al. Comprehensive analysis of kinase inhibitor selectivity. Nat.Biotechnol. 29(11), 1046-1051 (2011).
3.Mughal, A.,Aslam, H.M.,Sheikh, A., et al. c-Met inhibitors. Infect.Agent.Cancer 8, 13 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 632.7 |
| 分子式 | C34H34F2N4O6 |
| CAS号 | 849217-64-7 |
| 稳定性 | ≥ 2 years |
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