TW-37
货号：
20999-50mg 基本售价：
6552.0 元 规格：
50 mg
产品信息
概述| 货号 | 20999-50mg |
| 描述 | TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).1,2 It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.2 TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.2 It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Verhaegen, M.,Bauer, J.A.,de la Vega, C.M., et al. A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res. 66(23), 11348-11359 (2006).
2.Zeitlin, B.D.,Joo, E.,Dong, Z., et al. Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66(17), 8698-8706 (2006).
3.Azmi, A.S. and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J.Cell Physiol. 218(1), 13-21 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 573.7 |
| 分子式 | C33H35NO6S |
| CAS号 | 877877-35-5 |
| 稳定性 | ≥ 2 years |
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