| 货号 | 16167-5mg |
| 描述 | Ochratoxins are mycotoxins produced by AspergillusandPenicillium species of fungi that contaminate foods.1,2 Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.1,2 OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.3,4,5 OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.3 |
| 别名 | OTB; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Richard, J.L. Some major mycotoxins and their mycotoxicoses - An overview. Int.J.Food Microbiol. 119, 3-10 (2007). 2.Bennett, J.W. and Klich, M. Mycotoxins. Clin.Microbiol.Rev. 16(3), 497-516 (2003). 3.Knasmüller, S.,Cavin, C.,Chakraborty, A., et al. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment. Nutrition and Cancer 50(2), 190-197 (2004). 4.OBrien, E.,Prietz, A. and Dietrich, D.R. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res.B Dev.Reprod.Toxicol. 74(5), 417-423 (2005). 5.Mally, A.,Keim-Heusler, H.,Amberg, A., et al. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicology and Applied Pharmacology 206(1), 43-53 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 369.4 |
| 分子式 | C20H19NO6 |
| CAS号 | 4825-86-9 |
| 稳定性 | ≥ 2 years |
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