| 货号 | 16881-50mg |
| 描述 | Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) that activates toll-like receptor 3 and retinoic acid inducible gene 1 (RIG-1)-like receptors, including RIG-1 and melanoma differentiation associated gene 5.1 Through these actions, poly(I:C) activates NF-κB, induces IFN-α, promotes dendritic cell maturation, and stimulates both innate and adaptive immunity.2,3,4,5,6 As poly(I:C) imitates dsRNA found in some viral genomes, it bolsters immune defense against certain viruses.7 Poly(I:C) also directly triggers apoptosis in some cancer cells.1 |
| 别名 | Poly(I:C); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cheng, Y.S., and Xu, F. Anticancer function of polyinosinic-polycytidylic acid. Cancer Biology and Therapy 10(12), 1219-1223 (2010). 2.Robbins, M.A.,Maksumova, L.,Pocock, E., et al. Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 β-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor receptor-associated ligand (TRAIL). Endocrinology 144(10), 4616-4625 (2003). 3.Devendra, D.,Jasinski, J.,Melanitou, E., et al. Interferon-α as a mediator of polyinosinic: Polycytidylic acid-induced type 1 diabetes. Diabetes 54(9), 2549-2556 (2005). 4.Rouas, R.,Lewalle, P.,El Ouriaghli, F., et al. Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. International Immunology 16(5), 767-773 (2004). 5.West, A.P.,Brodsky, I.E.,Rahner, C., et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472(7344), 476-480 (2011). 6.Lin, Q.,Wang, L.,Lin, Y., et al. Toll-like receptor 3 ligand polyinosinic: Polycytidylic acid promotes wound healing in human and murine skin. Journal of Investigative Dermatology 132(8), 2085-2092 (2012). 7.Collier, M.A.,Gallovic, M.D.,Peine, K.J., et al. Delivery of host cell-directed therapeutics for intracellular pathogen clearance. Expert Rev.Anti.Infect.Ther. 11(11), 1225-1235 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 分子式 | (C10 H13 N4 O8 P)x • (C9 H14 N3 O8 P)x • XK |
| CAS号 | 31852-29-6 |
| 稳定性 | ≥ 1 year |
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