GSK3β Inhibitor VIII
货号：
14704-50mg 基本售价：
6496.0 元 规格：
50 mg
产品信息
概述| 货号 | 14704-50mg |
| 描述 | GSK3β Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM).1 It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM).1 GSK3β Inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death.1 |
| 别名 | AR 014418;AR 0133418;Glycogen Synthase Kinase 3β Inhibitor VIII;SN 4521; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bhat, R.,Xue, Y.,Berg, S., et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. The Journal of Biological Chemisty 278(46), 45937-45945 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.3 |
| 分子式 | C12H12N4O4S |
| CAS号 | 487021-52-3 |
| 稳定性 | ≥ 2 years |
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