IWP-L6
货号：
15243-50mg 基本售价：
6468.0 元 规格：
50 mg
产品信息
概述| 货号 | 15243-50mg |
| 描述 | Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.1 This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.1,2 IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).3 It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.3 In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.3 It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.3 |
| 别名 | PORCN Inhibitor III;Wnt Pathway Inhibitor XIX; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gao, X. and Hannoush, R.N. Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine. Nature Chemical Biology 10(10), 61-68 (2014).
2.Proffitt, K.D.,Madan, B.,Ke, Z., et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Research 73(2), 502-507 (2013).
3.Wang, X.,Moon, J.,Dodge, M.E., et al. The development of highly potent inhibitors for porcupine. Journal of Medicinal Chemistry 56(6), 2700-2704 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 472.6 |
| 分子式 | C25H20N4O2S2 |
| CAS号 | 1427782-89-5 |
| 稳定性 | ≥ 2 years |
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