| 货号 | 16013-10mg |
| 描述 | Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.1 AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.2,3PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.4 |
| 别名 | Dinoprost Ethanolamide;PGF2α-EA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bachur, N.R.,Masek, K.,Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. The Journal of Biological Chemisty 240, 1019-1024 (1965). 2.Yu, M.,Ives, D. and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. The Journal of Biological Chemisty 272, 21181-21186 (1997). 3.Kozak, K.R.,Crews, B.C.,Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. The Journal of Biological Chemisty 277(47), 44877-44885 (2002). 4.Woodward, D.F.,Tang-Liu, D.D.S.,Madhu, C., et al. Prostaglandin F2α(PGF2α) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications 27 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C22H39NO5 |
| CAS号 | 353787-70-9 |
| 稳定性 | ≥ 2 years |
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