(S)-Lisofylline
货号：
13617-10mg 基本售价：
6384.0 元 规格：
10 mg
产品信息
概述| 货号 | 13617-10mg |
| 描述 | LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.1,2 (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer.2 When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation.3 Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline. |
| 别名 | (+)-Lisofylline;(S)-LSF; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, Z.,Chen, M.,Ellett, J.D., et al. Inflammatory blockade improves human pancreatic islet function and viability. American Journal of Transplantation 5, 475-483 (2005).
2.Wyska, E.,Pekala, E., and Szymura-Oleksiak, J. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality 18, 644-651 (2006).
3.Lillibridge, J.A.,Kalhorn, T.F., and Slattery, J.T. Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol. Drug Metabolism and Disposition 24(11), 1174-1179 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 280.3 |
| 分子式 | C13H20N4O3 |
| CAS号 | 100324-80-9 |
| 稳定性 | ≥ 2 years |
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