| 货号 | 13616-10mg |
| 描述 | LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.1,2 (R)-LSF is the biologically active isomer of LSF.1,2 It is a potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.3 (R)-LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits interleukin 12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.4,1 |
| 别名 | (−)-Lisofylline;(R)-LSF; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yang, Z.,Chen, M.,Ellett, J.D., et al. Inflammatory blockade improves human pancreatic islet function and viability. American Journal of Transplantation 5, 475-483 (2005). 2.Wyska, E.,Pekala, E., and Szymura-Oleksiak, J. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality 18, 644-651 (2006). 3.Rice, G.C.,Brown, P.A.,Nelson, R.J., et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America 91, 3857-3861 (1994). 4.Yang, Z.D.,Chen, M.,Wu, R., et al. The anti-inflammatory compound lisofylline prevents type I diabetes in non-obese diabetic mice. Diabetologia 45, 1307-1314 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 280.3 |
| 分子式 | C13H20N4O3 |
| CAS号 | 100324-81-0 |
| 稳定性 | ≥ 2 years |
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